New research indicates that patients who come off blockbuster weight-loss injections like Mounjaro or Wegovy can put back on shed pounds at a significantly accelerated pace than those who stop traditional diet and exercise regimens.
Findings released in a prominent medical journal shows that while overweight individuals frequently drop a large proportion of their body weight while on the medication, the mass comes back at an estimated rate of nearly a kilo each month upon discontinuation.
"People using such drugs need to be informed of the risk of quick rebound weight gain when the medication is stopped," stated expert Dr. Susan Jebb.
This pace of regain suggests a reversion to starting weight in about one and a half years.
Weighing Treatments
The research, which reviewed dozens of studies involving over 9,000 of participants, compared the results of these new drugs with other pills.
Scientists note that individuals who lose weight through dieting typically experience a slower creep back—approximately 100 grams monthly—after stopping.
The Reason for the Fast Regain
Nutrition scientists propose the mode of action of the jabs is key to understanding the heightened weight return.
GLP-1 drugs imitate a natural hormone called glucagon-like peptide-1, which controls hunger.
"Artificially providing the hormone levels far above than normal could lead to the system to produce less of its own natural hormone, and could diminish responsiveness to its effects," said Dr. Adam Collins, a dietetics researcher.
"Stopping of this hormone supplement means appetite is uncontrolled, making binge eating a significant risk."
A Lifelong Disease?
Medical guidelines recommend the injections for people with weight-linked medical conditions, accompanied by recommended diet and exercise modifications.
Professionals contend that, considering the likelihood of relapse, the therapy might need to be life-long.
This opinion is echoed by pharmaceutical companies, who note that the results "highlight the long-term character of excess weight," akin to managing diseases like diabetes.
Patient Testimonies
People who have discontinued the medication describe a intense resurgence of cravings.
"It was like a trigger activating and I was suddenly ravenous," described a patient.
This difficulty is worsened if patients have not adopted lasting dietary or behavioural changes during therapy.
Significant Use
Figures suggest that millions of adults in the UK have tried these injections in the past year, with desire continuing to grow.
- Adoption is more common among females than males.
- The 40s and 50s age group shows the highest level of interest.
- Many obtain the medications through private prescriptions rather than public health services.
Finally, researchers stress that while GLP-1 drugs are effective tools for weight loss, they are not a permanent solution and maintained weight loss relies on integrated lifestyle support.
